Xu C, Li CYT, Kong ANT. UCSF Chimera- a visualization system for exploratory research and analysis. It needs frost protection. Hey AM, just happened to be researching and combing through the web looking up different test boosters and supplements containing some of these compounds touted at being big time natural test boosters and well reading several reviews/studies on one in particular by the name of bulbine … Int J Oncol. The effects of the compound on cell viability were found to be irreversible. It gets about a 1′ tall and spreads to about 2 feet. Bulbine natalensis is a succulent plant that grows in parts of South Africa. Bulbine frutescens is a traditional medicinal plant of South Africa, has been preliminarily reported for anti-proliferative and anti-drug resistance property in cancer cells. J Cheminform. Bolton EE, Wang Y, Thiessen PA, Bryant SH. The importance of Bulbine is high as its benefits are more and so are Bulbine Facts.Every gardener must look for the required information on this plant before planting it. EuroQSAR 2002 Designing Drugs and Crop Protectants: processes, problems and solutions. The juice of Bulbine annua, B. lagopus is said to have antibacterial and antifungal properties when applied externally. The authors declare that they have no conflict of interest. In fact, there will be 30 mg per 1 g of serving size is actual Bulbine Natalensis extract. 2007;28:1918–27. Planting and Care. Neoplasia. The effect was comparable to the anticancer agent BCNU. It hails from Africa and is a good groundcover plant for dry parts of the garden. Bulbine is a very important plant from Tender Perennial. Knipholone from. © Springer Nature Singapore Pte Ltd. 2019, Phytochemistry: An in-silico and in-vitro Update, https://doi.org/10.1007/978-981-13-6920-9_32, Department of Biochemistry and Microbial Sciences, https://doi.org/10.1007/978-981-13-6920-9_26. Note that the native leek (Bulbine bulbosa) is regarded as a toxic plant, as it can poison cattle. The PreADME approach: web-based program for rapid prediction of physico-chemical, drug absorption and drug-like properties. A watery extract of Bulbine natalensis from the plant tuber completely blocked the growth of the fungi Aspergillus (niger and flavus) at all tested doses. Bulbine frutescens (Asphodelaceae), a traditional medicinal plant in South Africa possess bioactive flavonoids and terpenoids. Bulbine bulbosa, Australia) especially to livestock, although the tubers of this and other species are roasted and eaten by bushmen. 2016;95:S8–S19. PubMed: Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. The present in silico study was designed to assess the potential B. frutescens phytochemicals as novel natural inhibitors of signaling proteins involved in cancer. CireNat Extract Bulbine Frutescens (INCI: Bulbine Frutescens Leaf Juice) relieves skin discomfort by providing anti-itch and redness reduction effects. Open babel: an open chemical toolbox. Mukanganyama S, Bezabih M, Robert M, Ngadjui BT, Kapche GF, Ngandeu F, Abegaz B. Early identification and prioritization of these natural products with potential for novel mechanism of action, desirable pharmacokinetics and likelihood for development into drugs is advantageous. This succulent perennial plant (ht 40 cm) grows in wide clumps with fleshy leaves and has dainty spires of yellow starry flowers mainly in spring but also at other times during the year. J Comput Chem. In conclusion, Palmidin C, AC1NSTKE and Bulbine-knipholone are the novel potent anticancer phytochemicals and need to be studied further in vitro and in vivo. Curr Opin Drug Dis Dev. 2011;3:33. In my experience, it multiplies rapidly. Flavonoids are an important class of phytochemical. Lee SK, Lee IH, Kim HJ, Chang GS, Chung JE, No KT. van Staden LF, Drewes SE. This includes the extract of Bulbine Natalensis. It has also been shown to exhibit potent aphrodisiac qualities. Another type of contrast, much used in the Pretoria NBG, is the inclusion of grey or whitish-leaved plants among the green ones. It makes a nice succulent ground cover and blooms throughout the year. Bulbine frutescens is often used in landscaping where a drought-resistant, tough groundcover is required.. ... Fenugreek seeds protect the liver from alcohol toxicity. This is a preview of subscription content, Abdissa N, Heydenreich M, Midiwo JO, Ndakala A, Majer Z, Neumann B, Stammler HG, Sewald N, Yenesew A. 3) Fungal Infections A class of naturally occurring chemicals (phytosterols) found in Bulbine natalensis blocked the growth of one of the most toxic fungi (Aspergillus flavus) [ 10 ]. Then, you can buy other forms of Bulbine Natalensis such as capsuled extract that sold by online markets. According to the concept of various signaling involvement in the development of cancer, fractional inhibition of numerous targets can be more productive than single one. Not logged in 2003;66:1475–83. Widgerow AD, Chait LA, Stals R, Stals PJ. 2009;12:189–96. Bulbine frutescens is a traditional medicinal plant of South Africa, has been preliminarily reported for anti-proliferative and anti-drug resistance property in cancer cells. The quinone moiety has been shown to possess antitumor activity and several cancer drugs in clinical use contain this entity. These active ingedients are contained in a pharmaceutically acceptable cream. Duvoix A, Morceau F, Delhalle S, Schmitz M, Schnekenburger M, Galteau MM, Dicato M, Diederich M. Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition. © 2020 Springer Nature Switzerland AG. Cancer Agenda. Bulbine frutescens Bulbine Natalensis is an herb from Southern and South Eastern Africa that has traditionally been used as an aphrodisiac as well as some other beneficial properties. New innovations in scar management. Bulbine. Lee KW, Kang NJ, Rogozin EA, Kim HG, Cho YY, Bode AM, Lee HJ, Surh YJ, Bowden GT, Dong Z. Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Some species of Bulbine have toxic foliage (e.g. The incisional wounds were used to test tensile strength of the healed wounds using a tensiometer.In the in vitro studies, neither extract caused cytotoxicity to either the fibroblast or keratinocyte cells. Bringmann G, Mutanyatta-Comar J, Maksimenka K, Wanjohi JM, Heydenreich M, Brun R, Müller WE, Peter MG, Midiwo JO, Yenesew A. Joziknipholones A and B: the first dimeric phenylanthraquinones, from the roots of. Lu L, Li K, Mao YH, Qu H, Yao B, Zhong WW, Ma B, Wang ZY. In fact, these flowers are often found in rock gardens with poor soil just for this reason. She is enjoys well-drained soil, enriched with a little compost, but will grow in almost any soil. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE. 2005;7:509–21. The isofuranonaphthoquinone occurs in Bulbine plant species such as Bulbine abyssinica, Bulbine capitata, and B. frutescens. van Huyssteen M, Milne PJ, Campbell EE, van de Venter M. Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. Bulbine frutescens works great as a low border plant in succulent gardens and could be used among rocks in xeriscape plantings. Cancer stem cell signaling pathways. 2008;4:217–41. Dallakyan S. PyRx-python prescription v. 0.8. 217.16.190.11. In conclusion, our study shows that the isofuranonaphthoquinone isolated from Bulbine frutescens possesses antiproliferative effects on Jurkat T cells. This succulent perennial plant (ht 40 cm) grows in wide clumps with fleshy leaves and has dainty spires of yellow starry flowers mainly in spring but also at other times during the year. 2010;31:455–61. Although normal cells also express caspase-3 genes during apoptosis, this study focused exclusively on the effect of Bulbine natalensis and B. frutescens fractions (selected relative to the cytotoxicity results of B. natalensis) on the HEp-2 cell line (read cell culture and … Wu T, Chen C, Li F, Chen Z, Xu Y, Xiao B, Tao Z. La Jolla: The Scripps Research Institute; 2010. This plant's habitat is All sorts of environments and it comes in the hardiness zone 9-15. pp 491-510 | Not affiliated Adaptation to this condition often resulted in chemotherapeutic resistance in cancer cells. The root, leaf, and stem are used as medicine. Anticancer and mode of action of various phytochemicals present in the plant not yet has been studied. Carcinogenesis. Over 10 million scientific documents at your fingertips. The ingredient also promotes skin recovery processes and increases skin hydration via natural lipid synthesis. Laskowski RA, Swindells MB. It is very easily propagated from division of the clump. A biochemical comparison of the in vivo effects of. 2000;24:227–34. Kinghorn AD, Chin YW, Swanson SM. It has been suggested that this is due to an activated form of HSP90 in tumor cells. 1998;12:66–73. Growing Bulbine Bulbine is very easy to grow, requiring little water and minimum care. The importance of plants lies in their great contribution to human life and the environment. 3,3′-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells. Unfortunately, the Amaryllis contains toxic substances like lycorine that is poisonous to cats if eaten. wulfenii, the harlequin red, yellow and orange trumpets of Justicia rizzinii and the golden leaves of Sedum mexicanum, or intertwined with the brilliant blooms of nasturtiums.The genus Bulbine belongs to the family Xanthorrhoeaceae, which includes genera such as Asphodelus, Dianella, Hemerocallis, Kniphofia and Phormium. Bulbine likes full sun, but will grow well in semi-shade. The evaluation of novel natural products as inhibitors of human glutathione transferase P1-1. Afr J Tradit Complement Altern Med. : improving the speed and accuracy of docking with a new scoring function, efficient optimization, and B..... 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